Monday, July 26, 2010

3 Dimensional(3D) Macromolecular

Deoxyribonucleic Acid(DNA) is the hereditary material in humans and almost all other organisms
DNA is made by chain of protein. Most DNA is located in the cell nucleus(where we call nuclear DNA).
The information in DNA is stored as a code made up of four chemical bases: adenine (A), guanine (G), cytosine (C), and thymine (T).DNA bases pair up with each other, A with T and C with G, to form units called base pairs. Each base is also attached to a sugar molecule and a phosphate molecule. Together, a base, sugar, and phosphate are called a nucleotide. Nucleotides are arranged in two long strands that form a spiral called a double helix.
An important property of DNA is that it can replicate, or make copies of itself. Each strand of DNA in the double helix can serve as a pattern for duplicating the sequence of bases. This is critical when cells divide because each new cell needs to have an exact copy of the DNA present in the old cell.

 Tetrapeptide KWKK conjugated to oligonucleotide duplex by a trimethylene tether
  
Journal: (2010) Biochemistry
Author:Huang, H.
             Kozekov, I.D.
             Kozekova, A.,  
             Rizzo, C.J.,  
             McCullough, A.K.
             Lloyd, R.S.
             Stone, M.P.


MOLECULAR DESCRIPTION

Classification: DNA Binding Protein/dna
Structure Weight: 7960.69
 
Molecule:5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3'


Polymer:1Type:polydeoxyribonucleotideLength:12
Chains:A


Molecule:5'-D(*GP*GP*AP*CP*TP*CP*GP*CP*TP*AP*GP*C)-3'
Polymer:2Type:polydeoxyribonucleotideLength:12
Chains:B


Molecule:KWKK Tetrapeptide
Polymer:3Type:polypeptide(L)Length:4
Chains:C

 

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